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Rhett, Joshua
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Wound Healing and the Foreign Body Response
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My work is aimed at elucidating the role that connexin channels play in ATP signaling during injuries. We hypothesize that microvascular endothelial cells near an injury release ATP, and attract inflammatory cells to wounded tissue. Although inflammation is a necessary component of wound healing, inflammatory cells can cause tissue damage. Understanding the molecular mechanisms behind this process could lead to therapies directed at dampening the inflammatory response during wound resolution, and improve the foreign body response to implanted materials and tissues.
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Rhett, Joshua